Hypochlorous Acid → N-chloro-2-methyl valeramide

HRID 1109268

反応式

HRID 1109268 の反応式
[CH2:1]([CH:3]([CH2:7][CH2:8][CH3:9])[C:4]([NH2:6])=[O:5])C.[Cl:10]O>C(OCC)(=O)C>[Cl:10][NH:6][C:4](=[O:5])[CH:3]([CH3:1])[CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 24341Hypochlorous AcidHCID 2031202-Ethylpentanamide

生成物 1

HCID 19022274N-chloro-2-methyl valeramide収率 76.7%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A stirred suspension of 2-ethyl valeramide (33.0 g, 286 mmol) in 220 ml of ethyl acetate was cooled to 0° and hypochlorous acid (55.25 g of 27.67% solution, 291 mmol) was added over 15 minutes. The cooling bath was removed and stirring continued for 1/2 hour. The organic phase was collected and dried (MgSO4) and the solvent was removed on a rotary evaporator to yield 32.8 g of N-chloro-2-methyl valeramide as a clear yellow liquid.

後処理

  1. temperaturewas cooled to 0°
  2. customThe cooling bath was removed
  3. customThe organic phase was collected
  4. dry with materialdried (MgSO4)
  5. customthe solvent was removed on a rotary evaporator

出典と根拠

ORDレコード
ord-653e491f8e8147b9aa0e9f5b8fb8b9aa
出典データセット
uspto-grants-1994_06
特許番号
US05319133

関連ノート

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