Ammonium Hydroxide → 2,2-Dimethylpentanamide

HRID 1109270

反応式

HRID 1109270 の反応式
[CH3:1][C:2]([CH3:9])([CH2:6][CH2:7][CH3:8])[C:3](Cl)=[O:4].[OH-].[NH4+:11]>>[CH3:1][C:2]([CH3:9])([CH2:6][CH2:7][CH3:8])[C:3]([NH2:11])=[O:4]

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 5191712,2-Dimethylvaleroyl chloride

生成物 1

HCID 831802,2-Dimethylpentanamide収率 86%

反応条件

温度
1 °C

実験手順

Ammonium hydroxide (250 ml) was stirred and cooled to 1° C. and 2,2-dimethyl valeroyl chloride (49.7 g, 95%, 318 mmol) was added dropwise over 30 minutes. After stirring at room temperature for an additional 1/2 hour, the white solid product was recovered by filtration, washed with water and allowed to air dry to give 35.4 g (86%) of the desired amide, mp 94°-95° (lit. mp 95°-96° C.).

後処理

  1. filtrationthe white solid product was recovered by filtration
  2. washwashed with water
  3. customto air dry

出典と根拠

ORDレコード
ord-3a9e20c6bbea417cae8668dd93d16f00
出典データセット
uspto-grants-1994_06
特許番号
US05319133

関連ノート

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