Hypochlorous Acid → N-chlor-2,2-dimethyl valeramide

HRID 1109271

反応式

HRID 1109271 の反応式
[CH3:1][C:2]([CH3:9])([CH2:6][CH2:7][CH3:8])[C:3]([NH2:5])=[O:4].[Cl:10]O>C(OCC)(=O)C>[Cl:10][NH:5][C:3](=[O:4])[C:2]([CH3:9])([CH3:1])[CH2:6][CH2:7][CH3:8]

参加物

4

反応物 2

HCID 24341Hypochlorous AcidHCID 831802,2-Dimethylpentanamide

生成物 1

HCID 19022270N-chlor-2,2-dimethyl valeramide収率 88.7%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
0 °C

実験手順

A stirred suspension of 2,2-dimethyl valeramide (35 g, 271 mmol) in ethyl acetate (200 ml) was cooled to 0° C. and hypochlorous acid (40.0 g of 36.2% solution, 276 mmol) was added dropwise over 12 minutes. The resulting clear yellow solution was then stirred for 30 minutes at room temperature, the organic phase separated and dried (MgSO4) and the ethyl acetate removed in vacuo to give 39.35 g of low-melting solid product.

後処理

  1. customthe organic phase separated
  2. dry with materialdried (MgSO4)
  3. customthe ethyl acetate removed in vacuo

出典と根拠

ORDレコード
ord-47a3c4770d9846749b355cca7ab1d623
出典データセット
uspto-grants-1994_06
特許番号
US05319133

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