1-Chloropropane → 1,3-Di-cyclopropylmethyl-7-n-propyl xanthine

反応式

[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[NH:12][CH:11]=[N:10][C:9]=3[N:8]([CH2:16][CH:17]3[CH2:19][CH2:18]3)[C:6]2=[O:7])[CH2:3][CH2:2]1.Cl[CH2:21][CH2:22][CH3:23]>>[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[N:12]([CH2:21][CH2:22][CH3:23])[CH:11]=[N:10][C:9]=3[N:8]([CH2:16][CH:17]3[CH2:19][CH2:18]3)[C:6]2=[O:7])[CH2:3][CH2:2]1

参加物

反応物 2

HCID 108991-Chloropropane

HCID 152913031,3-Dicyclopropylmethyl xanthine

生成物 1

HCID 231680071,3-Di-cyclopropylmethyl-7-n-propyl xanthine

実験手順

1,3-Di-cyclopropylmethyl-7-n-propyl xanthine was prepared from 1,3-di-cyclopropylmethyl xanthine and 1-chloropropane using an analogous procedure to that described in Example 5. The title compound was isolated as a crystalline solid, m.p. 67° C.

出典と根拠

ORDレコード: ord-f071d046fe3f49b59efd17554a1413e3
出典データセット: uspto-grants-1994_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05321029

反応ノート

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