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Triethylamine → N-Octadecyl-2-(4-amino-3-tert-butyl-5-methylphenylthio)succinimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-octadecyl-1H-pyrrole-2,5-dione | HCID 87118 | — |
| 反応物 | 2-Tert-butyl-4-mercapto-6-methylaniline | HCID 15324501 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-Octadecyl-2-(4-amino-3-tert-butyl-5-methylphenylthio)succinimide | HCID 15324511 | 56.4% |
反応手順
A stirred solution of 2.8 g (14 mmol) of 2-tert-butyl-4-mercapto-6-methylaniline, 5.0 g (14 mmol) of N-octadecylmaleimide and 0.1 g (1 mmol) of triethylamine in 50 mL of toluene is heated at 50° C. for 18 hours. The solvent is removed in vacuo and the residue is purified by preparative HPLC (silica gel, 4:1, heptane:ethyl acetate eluent) to give 4.3 g (55%) of the title compound as a caramel-colored liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05321067 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-d1dbe2ed3c4b43b4a331570ee8c496ba |
| 出典メモ | uspto-grants-1994_06 |