HRID1109670

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID87118

1-Octadecyl-1H-pyrrole-2,5-dione

C22H39NO2

HCID15324501

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCCN1C(=O)CC(Sc2cc(C)c(N)c(C(C)(C)C)c2)C1=O

HCID15324511

未命名化合物

收率 56.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A stirred solution of 2.8 g (14 mmol) of 2-tert-butyl-4-mercapto-6-methylaniline, 5.0 g (14 mmol) of N-octadecylmaleimide and 0.1 g (1 mmol) of triethylamine in 50 mL of toluene is heated at 50° C. for 18 hours. The solvent is removed in vacuo and the residue is purified by preparative HPLC (silica gel, 4:1, heptane:ethyl acetate eluent) to give 4.3 g (55%) of the title compound as a caramel-colored liquid.

WORKUP

后处理

customThe solvent is removed in vacuo
customthe residue is purified by preparative HPLC (silica gel, 4:1, heptane:ethyl acetate eluent)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d1dbe2ed3c4b43b4a331570ee8c496ba
来源数据集: uspto-grants-1994_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05321067
来源说明: uspto-grants-1994_06

反应 SMILES

[C:1]([C:5]1[CH:11]=[C:10]([SH:12])[CH:9]=[C:8]([CH3:13])[C:6]=1[NH2:7])([CH3:4])([CH3:3])[CH3:2].[CH2:14]([N:32]1[C:36](=[O:37])[CH:35]=[CH:34][C:33]1=[O:38])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:14]([N:32]1[C:33](=[O:38])[CH2:34][CH:35]([S:12][C:10]2[CH:9]=[C:8]([CH3:13])[C:6]([NH2:7])=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:11]=2)[C:36]1=[O:37])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]