化工社化工社 化学情報印刷レポート · 研究参考用
3-Hydroxybenzyl alcohol → 2,7-Naphthalenediol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxybenzyl alcohol | HCID 102 | — |
| 反応物 | 2-(Chloromethyl)-5-(trifluoromethyl)-1,3-benzothiazole | HCID 14204205 | — |
| 反応物 | 3-(5-Trifluoromethylbenzothiazol-2-ylmethoxy)benzyl alcohol | HCID 53867966 | — |
| 生成物 | 2,7-Naphthalenediol | HCID 11397 | — |
| 生成物 | 2-(Chloromethyl)-6-fluoroquinoline | HCID 11241007 | — |
| 生成物 | Benzothiazole, 2-(chloromethyl)-5-fluoro- (9CI) | HCID 14204210 | — |
| 生成物 | 2-(5-Fluorobenzothiazol-2-ylmethoxy)-7-hydroxynaphthalene | HCID 19019454 | — |
反応手順
In a similar manner, starting with 2-chloromethyl-5-trifluoromethylbenzothiazole and 3-hydroxy benzyl alcohol and following this procedure, 3-(5-trifluoromethylbenzothiazol-2-ylmethoxy)benzyl alcohol was prepared, m.p. 117°-119° C., 2-chloromethyl-5-fluorobenzothiazole and 2,7-dihydroxynaphthalene gave 2-(5-fluorobenzothiazol-2-ylmethoxy)-7-hydroxynaphthalene, m.p. 218°-220° C., 2-chloromethyl-6-fluoroquinoline and m-resorcinol gave 3-(6-fluorocruinol-2-ylmethoxy)phenol, m.p. 146°-148° C. and 2-chloromethyl-5-fluorobenzothiazol and methyl 3-hydroxymandelate gave methyl 3-(5-fluorobenzothiazol-2-ylmethoxy)mandelate, m.p. 99°-101° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05322847 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-6b4668dbade64491afd029d8e78a6fd4 |
| 出典メモ | uspto-grants-1994_06 |