Sodium Carbonate → 4,5-Dichloro-4-fluoro-3,4,5,6-tetrahydrophthalic anhydride

HRID 1109827

反応式

HRID 1109827 の反応式
[Cl:1][C:2]1[CH2:3][C:4]2[C:9](=[O:10])[O:8][C:6](=[O:7])[C:5]=2[CH2:11][CH:12]=1.[Cl:13]N1C(=O)CCC1=O.C1C=CN=CC=1.[FH:27].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[Cl:1][C:2]1([F:27])[CH:12]([Cl:13])[CH2:11][C:5]2[C:6]([O:8][C:9](=[O:10])[C:4]=2[CH2:3]1)=[O:7]

参加物

6

反応物 4

HCID 10340Sodium CarbonateHCID 31398ChlorosuccinimideHCID 64774Pyridine, hydrofluoride (1:1)HCID 109869774-Chloro-3,6-dihydrophthalic anhydride

生成物 1

HCID 542227594,5-Dichloro-4-fluoro-3,4,5,6-tetrahydrophthalic anhydride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

4-chloro-3,6-dihydrophthalic anhydride (0.63 g) and N-chlorosuccinimide (0.47 g) in methylene chloride (6.2 ml) was added to pyridinium poly(hydrogen fluoride) at room temperature. The reaction mixture was stirred for 2 hours and then carefully poured into a two phase system containing solid sodium carbonate and methylene chloride. The suspension was filtered, the methylene chloride layer was dried over magnesium sulfate and the solvent removed under reduced pressure.

後処理

  1. additioncarefully poured into a two phase system
  2. filtrationThe suspension was filtered
  3. dry with materialthe methylene chloride layer was dried over magnesium sulfate
  4. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-4dd89edc0a244d408f3a9325994de888
出典データセット
uspto-grants-1994_06
特許番号
US05322954

関連ノート

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