Ethanolamine → HCID 19694659、化合物

HRID 1110ノート

反応式

HRID 1110 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH2:5]([O:19][CH2:20][CH:21]1[O:25][C:22]1([CH3:24])[CH3:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH:21]([CH2:20][O:19][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:22]([CH3:24])([OH:25])[CH3:23]

参加物

4

反応物 2

HCID 700EthanolamineHCID 196945961-Tetradecyloxy-3-methyl-2-butene oxide

生成物 1

HCID 19694659HCID 19694659、化合物収率 58%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
80 °C

実験手順

A 100-ml two-necked flask equipped with a stirrer and a dropping funnel was charged with 15.3 g (16.7 mmol) of ethanolamine and 5.0 g of ethanol. While heating and stirring the mixture at 80° C. in a nitrogen atmosphere, an ethanol solution of 5.00 g (16.7 mmol) of 1-tetradecyloxy-3-methyl-2-butene oxide was added dropwise over 3 hours. After heating and stirring the mixture further for 16 hours, the resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 3.47 g (yield: 58%) of the title compound (IIc-4).

後処理

  1. customA 100-ml two-necked flask equipped with a stirrer and a dropping funnel
  2. temperatureWhile heating
  3. temperatureAfter heating
  4. stirringstirring the mixture further for 16 hours
  5. customthe resultant reaction mixture
  6. concentrationwas concentrated under reduced pressure
  7. customthe resultant residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-e403979772a141b9b46f8ea7de5203df
出典データセット
uspto-grants-1998_03
特許番号
US05723497

反応ノート

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