Sodium Carbonate → Spiro[indene-1,4'-piperidine]

HRID 1110044ノート

反応式

HRID 1110044 の反応式
Cl.[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[Na+].[Na+]>O>[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 22509344Spiro[indene-1,4'-piperidine] hydrochloride

生成物 1

HCID 10330052Spiro[indene-1,4'-piperidine]

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Spiro[1H-indene-1,4'-piperidine]hydrochloride (400 mg, 1.8 mmol), prepared according to Example 1, step 3, was dissolved in water (10 ml), and the solution made alkaline with sodium carbonate. The mixture was extracted with dichloromethane (3×10 ml), the organic layers separated, dried (MgSO4) and evaporated in vacuo. The free base was used without any further purification.

後処理

  1. extractionThe mixture was extracted with dichloromethane (3×10 ml)
  2. customthe organic layers separated
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo
  5. customThe free base was used without any further purification

出典と根拠

ORDレコード
ord-200b2f52d402459d8bef0f27cc92a81d
出典データセット
uspto-grants-1994_06
特許番号
US05324733

反応ノート

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