Water → HCID 178441902、化合物

HRID 1110119ノート

反応式

HRID 1110119 の反応式
[N+:1]([O-])([O-])=O.[Na+].[C:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[NH2:18])#[C:7][CH2:8][CH2:9][CH2:10][CH3:11].[OH2:19]>Cl>[CH2:8]([C:7]1[N:1]=[N:18][C:13]2[C:12]([C:6]=1[OH:19])=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH3:11]

参加物

5

反応物 3

HCID 962Water2 回HCID 24268Sodium NitrateHCID 107973102-(Hex-1-yn-1-yl)aniline

生成物 1

HCID 178441902HCID 178441902、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
0 °C

実験手順

A solution of 2 g of sodium nitrate in 60 ml of water was added at 0° C. to a suspension at 0° C. of 3.2 g of the product of Step A in 100 ml of concentrated hydrochloric acid. The mixture was stirred for 90 minutes at 0° C., then for one hour at 100° C. The reaction medium was poured into 100 ml of ice-cooled water, followed by separating and washing with ice-cooled water. The moist product was taken up in 100 ml of water and alkalized with concentrated ammonium hydroxide. After separating, the residue was washed with water and dried at 70° C. under reduced pressure to obtain 1.47 g of the expected product melting at 180° C.

後処理

  1. waitfor one hour at 100° C
  2. customby separating
  3. washwashing with ice-
  4. temperaturecooled water
  5. customAfter separating
  6. washthe residue was washed with water
  7. customdried at 70° C. under reduced pressure

出典と根拠

ORDレコード
ord-b8d2622fb0d54a8889ab4f0e945e37b0
出典データセット
uspto-grants-1994_06
特許番号
US05324839

反応ノート

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