1,3-Dibromopropane → 1-Bromo-3-(3-bromopropoxy)benzene
反応式
[Br:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[Br:9][CH2:10][CH2:11][CH2:12]Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:9][CH2:10][CH2:11][CH2:12][O:8][C:4]1[CH:3]=[C:2]([Br:1])[CH:7]=[CH:6][CH:5]=1参加物
5
実験手順
A mixture of 5.0 g (0.029 mol) of 3-bromophenol, 29 ml (0.29 mol) of 1,3-dibromopropane and 12 g (0.087 mol) of potassium carbonate in 75 ml of acetone was stirred at reflux for 22 ours. The reaction mixture was filtered and the filtrate was concentrated at reduced pressure. The residue was purified by HPLC using 3% ethyl acetate-hexane to give 4.9 g (58% yield) of 3-(3-bromopropoxy)bromobenzene. The structure was confirmed by the nmr spectrum.
後処理
- temperatureat reflux for 22 ours
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated at reduced pressure
- customThe residue was purified by HPLC
出典と根拠
- ORDレコード
- ord-c01d10dd6b914b0898040f4528af829d
- 出典データセット
- uspto-grants-1994_06
- 特許番号
- US05324747
反応ノート
読み込み中…