Triphenylphosphine → (4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride

HRID 1110411ノート

反応式

HRID 1110411 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Cl:9])=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O1CCCC1>[Cl-:9].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][P+:23]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 135636494-(Chloromethyl)-1-fluoro-2-phenoxybenzene

生成物 1

HCID 19754846(4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride収率 60.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 11.8 grams (0.05 mole) of 4-fluoro--3-phenoxyphenylmethyl chloride and 13.1 grams (0.05 mole) of triphenylphosphine in 150 mL of dry tetrahydrofuran was stirred for 72 hours. After this time the reaction mixture was concentrated under reduced pressure to a residual solid. The residue was stirred with diethyl ether and filtered to collect the solid. The solid was washed repeatedly with diethyl ether and dried yielding 15.0 grams of 4-fluoro-3-phenoxyphenylmethyltriphenylphosphonium chloride.

後処理

  1. concentrationAfter this time the reaction mixture was concentrated under reduced pressure to a residual solid
  2. filtrationfiltered
  3. customto collect the solid
  4. washThe solid was washed repeatedly with diethyl ether
  5. customdried

出典と根拠

ORDレコード
ord-abab2ad225ab43298b07b82f686be21a
出典データセット
uspto-grants-1990_12
特許番号
US04975451

反応ノート

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