Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → (E)-5,5-bis(4-methylphenyl)-2,4-pentadienoic acid

HRID 1110556ノート

反応式

HRID 1110556 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)=[CH:9][CH:10]=O)=[CH:4][CH:3]=1.[C:19]([CH:23]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:21]C)=[O:20]>C(Cl)(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)=[CH:9]/[CH:10]=[CH:23]/[C:19]([OH:21])=[O:20])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 17453Acetic acid, 2-(triphenylphosphoranylidene)-, methyl esterHCID 127223653,3-Bis(4-methylphenyl)-2-propenal

生成物 1

HCID 14347262(E)-5,5-bis(4-methylphenyl)-2,4-pentadienoic acid収率 67.4%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

In the manner described in Example 99, 3,3-bis(4-methylphenyl) -2-propenal (9.45 g) was reacted with (carbomethoxymethylene)triphenylphosphorane (15.3 g) in carbon tetrachloride (95 ml) for 3 days at room temperature. The solvent was removed under reduced pressure and the residue was stirred at reflux in mixture of methanol (40 mL) and 2N NaOH for 45 minutes. The cooled solution was diluted with water (300 ml), extracted with dichloromethane (3×100 mL) to remove non-acidic material, and then acidified with 6N HCI (50 ML) and extracted with dichloromethane. The dried (MgSO4) extracts were evaporated and the crude product was crystallized from 2-propanol to afford 7.5 g of (E)-5,5-bis(4-methylphenyl)-2,4-pentadienoic acid, mp 224 5°-226.5° C.

後処理

  1. customThe solvent was removed under reduced pressure
  2. temperatureat reflux in mixture of methanol (40 mL) and 2N NaOH for 45 minutes
  3. additionThe cooled solution was diluted with water (300 ml)
  4. extractionextracted with dichloromethane (3×100 mL)
  5. customto remove non-acidic material
  6. extractionextracted with dichloromethane
  7. dry with materialThe dried (MgSO4) extracts
  8. customwere evaporated
  9. customthe crude product was crystallized from 2-propanol

出典と根拠

ORDレコード
ord-f9d4f616be81492c90884af7fdc60731
出典データセット
uspto-grants-1990_12
特許番号
US04975438

反応ノート

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