p-Bromochlorobenzene → 1-Chloro-4-(4-methoxyphenoxy)benzene

HRID 1110657ノート

反応式

HRID 1110657 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][CH:3]=1.[CH3:9][O:10][C:11]1[CH:17]=[CH:16][C:14]([OH:15])=[CH:13][CH:12]=1.[OH-].[K+]>[Cu]>[CH3:9][O:10][C:11]1[CH:17]=[CH:16][C:14]([O:15][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][CH:3]=2)=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 7806p-BromochlorobenzeneHCID 90154-MethoxyphenolHCID 14797Potassium Hydroxide

生成物 1

HCID 101054561-Chloro-4-(4-methoxyphenoxy)benzene収率 53.7%

試薬・触媒・溶媒 1

HCID 23978Copper触媒

実験手順

4-Bromochlorobenzene (3.8 g), hydroquinone monomethyl ether (3.1 g) and potassium hydroxide (1.5 g) and copper powder (0.1 g) were mixed and the reaction was carried out at 160° C. to 200° C. for 3 hours. After cooling to room temperature, the reaction mixture was extracted with benzene (100 ml) and washed with 1N sodium hydroxide, water, and saturated aqueous sodium chloride. After drying over anhydrous magnesium sulfate, the solvent was evaporated under a reduced pressure and the residue was purified by medium pressure column chromatography using silica gel, to obtain 4-(4-chlorophenoxy)phenol methyl ether (2.5 g).

後処理

  1. extractionthe reaction mixture was extracted with benzene (100 ml)
  2. washwashed with 1N sodium hydroxide, water, and saturated aqueous sodium chloride
  3. dry with materialAfter drying over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under a reduced pressure
  5. customthe residue was purified by medium pressure column chromatography

出典と根拠

ORDレコード
ord-6c734cefce64484499d178a44cd021c7
出典データセット
uspto-grants-1990_12
特許番号
US04976773

反応ノート

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