Diethylamine → N,N-Diethyl-3-nitrobenzenesulfonamide

HRID 1110672ノート

反応式

HRID 1110672 の反応式
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[N+:6]([C:9]1[CH:10]=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1)([O-:8])=[O:7]>N1C=CC=CC=1.C(Cl)Cl>[CH2:1]([N:3]([CH2:4][CH3:5])[S:15]([C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([N+:6]([O-:8])=[O:7])[CH:10]=1)(=[O:16])=[O:17])[CH3:2]

参加物

5

反応物 2

HCID 8021DiethylamineHCID 84763-Nitrobenzenesulfonyl chloride

生成物 1

HCID 232031N,N-Diethyl-3-nitrobenzenesulfonamide収率 51.2%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒2 回HCID 6344Dichloromethane溶媒

反応条件

温度
50 °C

実験手順

Diethylamine (2.4 g) was dissolved in pyridine (15 ml) and 3-nitrobenzenesulfonyl chloride (6.7 g) was added, followed by stirring at 50° C. for 2 hours. The residue obtained by an evaporation of pyridine under a reduced pressure was dissolved in methylene chloride (150 ml), washed with water, 1N hydrochloric acid, water, and saturated aqueous sodium chloride, and dried over anhydrous sodium sulfate. Evaporation of the solvent under a reduced pressure gave N,N-diethyl-3-(nitro)benzenesulfonamide (4.0 g).

後処理

  1. washwashed with water, 1N hydrochloric acid, water, and saturated aqueous sodium chloride
  2. dry with materialdried over anhydrous sodium sulfate
  3. customEvaporation of the solvent under a reduced pressure

出典と根拠

ORDレコード
ord-aa3aa13b3bb74602b666f316a8a8d088
出典データセット
uspto-grants-1990_12
特許番号
US04976773

反応ノート

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