Sodium Hydroxide → HCID 398448、化合物

HRID 1110932ノート

反応式

HRID 1110932 の反応式
[OH-].[Na+].Cl[CH2:4][C:5]([NH:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11])=[O:6]>O.C(O)(C)C>[NH:7]1[C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](=[O:12])[O:11][CH2:4][C:5]1=[O:6]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 919916HCID 919916、化合物

生成物 1

HCID 398448HCID 398448、化合物収率 87%

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 3776Isopropanol溶媒

反応条件

温度
80 °C

実験手順

A solution of sodium hydroxide (2 g, 50 mole) in water (12 ml) was added to a stirred slurry of 2-chloroacetamidobenzoic acid (10.3 g, 48 mmole) in isopropanol (22.5 ml) and water (87.5 ml). The mixture was stirred until a solution formed and then heated at 80° C. for 4 hours. The solution was cooled to 0° C. and the crystalline solid collected, washed with water and dried in vacuo at 50° C. to give the product (7.4 g, 87%), m.p. 200°-201° C.

後処理

  1. customformed
  2. temperatureThe solution was cooled to 0° C.
  3. customthe crystalline solid collected
  4. washwashed with water
  5. customdried in vacuo at 50° C.

出典と根拠

ORDレコード
ord-2bd37286434e4825823a739ce84aaaae
出典データセット
uspto-grants-1990_12
特許番号
US04977258

反応ノート

読み込み中…