Succinic anhydride → 4-Chloro-3-succinimido-5-sulphamylbenzoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([Cl:14])=[C:6]([NH2:15])[CH:5]=1.[C:17]1(=O)[O:22][C:20](=[O:21])[CH2:19][CH2:18]1>CO>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([Cl:14])=[C:6]([N:15]2[C:20](=[O:21])[CH2:19][CH2:18][C:17]2=[O:22])[CH:5]=1参加物
4
実験手順
25.4 g of 4-chloro-3-amino-5-sulphamyl-benzoic acid methyl ester, m.p. 195°-196° C., are thoroughly mixed with 25 g of succinic acid anhydride and melted for 6 hours at 180° C. The melt is allowed to cool slowly and CH3OH is added carefully. The product crystallizes. A small amount of water added completes the crystallisation.
後処理
- temperatureto cool slowly