Hydrochloric Acid → alpha-Phenyl[1,1'-biphenyl]-4-methanol

HRID 1111656

反応式

HRID 1111656 の反応式
[C:1]1([C:7]2[CH:20]=[CH:19][C:10]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+].O.Cl>C(O)C>[C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]=[CH:9][C:10]([CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[OH:12])=[CH:19][CH:20]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 750404-BenzoylbiphenylHCID 4311764Sodium borohydride

生成物 1

HCID 95512alpha-Phenyl[1,1'-biphenyl]-4-methanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

38.8 g (0.15 mol) of 4-phenylbenzophenone are dissolved in 200 ml of ethanol and 3 g (0.075 mol) of sodium borohydride are added. After heating for 15 hours under reflux, and allowing to cool, the reaction mixture is hydrolyzed with water containing a little hydrochloric acid. The solid thereby produced is purified by recrystallization from ethanol. 36 g (89% of theory) of (biphenyl-4-yl)-phenyl-carbinol [alternatively named as diphenyl-phenyl carbinol or α-(biphenyl-4-yl)benzylalcohol] of melting point 72°-73° C. are obtained.

後処理

  1. temperatureAfter heating for 15 hours
  2. temperatureunder reflux
  3. temperatureto cool
  4. customThe solid thereby produced
  5. customis purified by recrystallization from ethanol
  6. customare obtained

出典と根拠

ORDレコード
ord-45182ab4d29b44818040161a2a1e24d8
出典データセット
uspto-grants-1978_10
特許番号
US04118487

関連ノート

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