Potassium thiocyanate → HCID 20387432、化合物

HRID 1112216ノート

反応式

HRID 1112216 の反応式
Cl.Cl[CH2:3][CH2:4][S:5][CH2:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[CH3:12].[S-:13][C:14]#[N:15].[K+]>C(O)C>[CH3:12][C:11]1[NH:10][CH:9]=[N:8][C:7]=1[CH2:6][S:5][CH2:4][CH2:3][S:13][C:14]#[N:15]

参加物

4

反応物 2

HCID 516872Potassium thiocyanateHCID 132173611-Chloro-2(5-methyl-4-imidazolylmethylthio)ethane hydrochloride

生成物 1

HCID 20387432HCID 20387432、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-Chloro-2-(5-methyl-4-imidazolylmethylthio)ethane hydrochloride (2.1 g) and potassium thiocyanate (0.97 g) were heated together under reflux in ethanol (50 ml) for 3 days. The mixture was evaporated to dryness and the residue was taken up in water, basified with sodium carbonate and extracted with chloroform. The chloroform extracts were dried (MgSO4) and evaporated to a residue which was recrystallised from acetonitrile to give 2-(5-methyl-4-imidazolylmethylthio)ethylthiocyanate m.p. 101°-103°.

後処理

  1. customThe mixture was evaporated to dryness
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform extracts were dried (MgSO4)
  4. customevaporated to a residue which
  5. customwas recrystallised from acetonitrile

出典と根拠

ORDレコード
ord-422e81b026a444f69b21541683d3893e
出典データセット
uspto-grants-1978_10
特許番号
US04120966

反応ノート

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