4-[(cyclohexylamino)methyl]-3,3-diphenyldihydro-2(3H)-furanone → 1-Cyclohexyl-4-hydroxymethyl-3,3-diphenyl-2-pyrrolidinone

HRID 1112274ノート

反応式

HRID 1112274 の反応式
[CH:1]1([NH:7][CH2:8][CH:9]2[CH2:13][O:12][C:11](=[O:14])[C:10]2([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>[H-].[Na+].C(CC(C)(C)C)(C)C>[CH:1]1([N:7]2[CH2:8][CH:9]([CH2:13][OH:12])[C:10]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:11]2=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

4

反応物 1

HCID 128222864-[(cyclohexylamino)methyl]-3,3-diphenyldihydro-2(3H)-furanone

生成物 1

HCID 128222881-Cyclohexyl-4-hydroxymethyl-3,3-diphenyl-2-pyrrolidinone収率 73%

試薬・触媒・溶媒 2

HCID 24758Sodium hydride触媒HCID 109072,2,4-Trimethylpentane溶媒

実験手順

To 90.0 g. (0.26 mole) of 4-cyclohexylaminomethyl-4,5-dihydro-3,3-diphenylfuran-2-(3H)one in 500 ml. of isooctane was added 1.0 g. of sodium hydride (57% in mineral oil) as a catalyst and the mixture was refluxed overnight. Upon cooling a solid precipitated and the isooctane was decanted from the solid. The solid was recrystallized from isopropyl alcohol, weighed 66.0 g. (73% yield) and melted at 148°-150° C.

後処理

  1. temperatureUpon cooling a solid
  2. customprecipitated
  3. customthe isooctane was decanted from the solid
  4. customThe solid was recrystallized from isopropyl alcohol

出典と根拠

ORDレコード
ord-f81945489cd3466cbb94351cf89a84d3
出典データセット
uspto-grants-1978_10
特許番号
US04120969

反応ノート

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