Ethyl Acetate → cis-3-Azido-4-oxo-2-azetidinylmethyl bromide

HRID 1112344ノート

反応式

HRID 1112344 の反応式
S(C1C=CC(C)=CC=1)(O[CH2:5][C@H:6]1[C@@H:9]([N:10]=[N+:11]=[N-:12])[C:8](=[O:13])[NH:7]1)(=O)=O.[Li+].[Br-:22].C(OCC)(=O)C>CN(C)C=O>[N:10]([C@H:9]1[C:8](=[O:13])[NH:7][C@H:6]1[CH2:5][Br:22])=[N+:11]=[N-:12]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 82050Lithium BromideHCID 86734335HCID 86734335、化合物

生成物 1

HCID 86736078cis-3-Azido-4-oxo-2-azetidinylmethyl bromide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A degassed solution of cis-3-azido-4-oxo-2-azetidinylmethyl tosylate (0.41 g, 1.4 mmol) in dimethylformamide (5 ml) was heated to 90° with LiBr (0.43 g, 5 mmol) for 4 hours. The reaction was poured into ethyl acetate and washed copiously with water. The dried solution was evaporated to give the title compound.

後処理

  1. washwashed copiously with water
  2. customThe dried solution was evaporated

出典と根拠

ORDレコード
ord-7f9dc7402b6f40cfba065dd4816442d6
出典データセット
uspto-grants-1978_10
特許番号
US04122086

反応ノート

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