Aspirin → Vincamine acetylsalicylate

HRID 1112366

反応式

HRID 1112366 の反応式
[C:1]([O:4][C:5]1[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].[CH3:14][CH2:15][C@:16]12[CH2:32][C@:31]([OH:37])([C:33]([O:35][CH3:36])=[O:34])[N:30]3[C:22]4=[C:23]([CH2:38][CH2:39][N:20]([C@@H:21]14)[CH2:19][CH2:18][CH2:17]2)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=13>C(O)C.C(Cl)(Cl)Cl>[CH3:14][CH2:15][C@:16]12[CH2:32][C@:31]([OH:37])([C:33]([O:35][CH3:36])=[O:34])[N:30]3[C:22]4=[C:23]([CH2:38][CH2:39][N:20]([C@@H:21]14)[CH2:19][CH2:18][CH2:17]2)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=13.[C:1]([O:4][C:5]1[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:7]([O-:9])=[O:8])(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 2244AspirinHCID 15376Vincamine

生成物 1

HCID 86736089Vincamine acetylsalicylate

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 6212Chloroform溶媒

反応条件

温度
70 °C

実験手順

A solution of 3.6 g (2.10-` moles) of acetylsalicylic acid in 30 mls of ethanol is added to a solution of 7.08 g (2.10-2 moles) of vincamine in 80 mls of ethanol and 60 mls of CHCl3. The mixture is maintained under stirring at 70° C. for 10 minutes and then concentrated to 60 mls. The residue is taken with ethanol (70 mls) and the solvent is evaporated to a final volume of 15 mls.

後処理

  1. temperatureThe mixture is maintained
  2. concentrationconcentrated to 60 mls
  3. customthe solvent is evaporated to a final volume of 15 mls

出典と根拠

ORDレコード
ord-58e56f3178c24e31977211f621595d8e
出典データセット
uspto-grants-1978_10
特許番号
US04122179

関連ノート

読み込み中…