Formaldehyde → [2-(4-Methylphenyl)-1H-imidazole-4,5-diyl]dimethanol

反応式

[C:1]1([CH3:12])[CH:6]=[CH:5][C:4]([C:7]2[NH:8][CH:9]=[CH:10][N:11]=2)=[CH:3][CH:2]=1.[CH2:13]=[O:14].[OH-].[K+].[CH3:17][O:18]CCO>>[C:1]1([CH3:12])[CH:2]=[CH:3][C:4]([C:7]2[NH:11][C:10]([CH2:13][OH:14])=[C:9]([CH2:17][OH:18])[N:8]=2)=[CH:5][CH:6]=1

参加物

反応物 4

HCID 712Formaldehyde

HCID 80192-Methoxyethanol

HCID 14797Potassium Hydroxide

HCID 5940452-(4-Methylphenyl)-1H-imidazole

生成物 1

HCID 22764401[2-(4-Methylphenyl)-1H-imidazole-4,5-diyl]dimethanol収率 9%

実験手順

A mixture of 15.8 g (0.1 mole) of 2-p-tolylimidazole, 24 ml (0.3 mole) of 37% formalin and 2 g of potassium hydroxide was heated for 30 minutes with stirring in the same way as in Example 1, and the reaction mixture was post-treated in the same way as in Example 1 except that methyl cellosolve was used instead of methanol as a recrystallization solvent to afford 2-p-tolyl-4,5-dihydroxymethyl imidazole as a final product in an amount of 2 g (yield 9%).