Hydrochloric Acid → trans-Aconitic acid

HRID 1112608

反応式

HRID 1112608 の反応式
[OH-].[Ca+2].[OH-].Cl.[C:5]([OH:17])(=[O:16])[CH:6]([CH:8]([CH2:12][C:13]([OH:15])=[O:14])[C:9]([OH:11])=[O:10])O>O>[CH2:12]([C:13]([OH:15])=[O:14])/[C:8](/[C:9]([OH:11])=[O:10])=[CH:6]\[C:5]([OH:17])=[O:16]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 1198Isocitric AcidHCID 6093208Calcium Hydroxide2 回

生成物 1

HCID 444212trans-Aconitic acid収率 60%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
75 °C

実験手順

Thirty one grams (0.1 mole) of product prepared as in Example I-B is mixed with 200 mls water. Thirty grams (0.4 mole) calcium hydroxide is added slowly while the pH of the reaction medium is maintained at 10-10.5 and the temperature is kept between 70° and 75° C. After the addition of calcium hydroxide is complete, the reaction mixture is stirred at 75° C. for an additional two hours and then cooled. 90 grams of a 20% by weight hydrochloric acid solution is added slowly to a pH of 1.3 and the resulting solution is then filtered. The filtrate is evaporated to dryness in vacuo and the residue extracted with acetone. The acetone extract is filtered and 19.5 grams of product consisting of 53.5% (60% yield) transaconitic acid and 5.8% of a mixture of lactones of isocitric acid and alloisocitric acid.

後処理

  1. temperatureis maintained at 10-10.5
  2. customis kept between 70° and 75° C
  3. temperaturecooled
  4. filtrationthe resulting solution is then filtered
  5. customThe filtrate is evaporated to dryness in vacuo
  6. extractionthe residue extracted with acetone
  7. extractionThe acetone extract
  8. filtrationis filtered

出典と根拠

ORDレコード
ord-e6bcbd2ae41c499eb49e303d3f558a72
出典データセット
uspto-grants-1978_10
特許番号
US04123459

関連ノート

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