Ethanolamine → 1-(2-Hydroxyethylamino)-2,16-hexadecanediol

HRID 1113

反応式

HRID 1113 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].N#N.[O:7]1[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])[CH2:8]1>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH2:8][CH:9]([OH:7])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24]

参加物

5

反応物 3

HCID 700Ethanolamine2 回HCID 947NitrogenHCID 196946001,2-Epoxy-16-hexadecanol

生成物 1

HCID 196946261-(2-Hydroxyethylamino)-2,16-hexadecanediol収率 68%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒3 回

実験手順

A 50-ml two-necked flask equipped with a stirrer, dropping funnel and N2 inlet tube was charged with 4.14 g (68 mmol) of ethanolamine and 0.8 g of ethanol. While heating and stirring the mixture at 80° C. in an N2 atmosphere, an ethanol solution of 0.87 g (3.4 mmol) of 1,2-epoxy-16-hexadecanol was added dropwise over 1.5 hours. The resultant mixture was stirred further for 2 hours at 80° C. After completion of the reaction, ethanol and excess ethanolamine were distilled off under reduced pressure, and the resultant residue was purified by flash column chromatography on silica gel, thereby obtaining 0.72 g (yield: 68%) of the title compound (IId-1).

後処理

  1. customA 50-ml two-necked flask equipped with a stirrer
  2. temperatureWhile heating
  3. distillationwere distilled off under reduced pressure
  4. customthe resultant residue was purified by flash column chromatography on silica gel

出典と根拠

ORDレコード
ord-c54f235e113e4ef68f3a56e016403a66
出典データセット
uspto-grants-1998_03
特許番号
US05723497

関連ノート

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