Methyl morpholine oxide → 4-(2-Chlorophenyl)-6-(2,3-dihydroxypropyl)-2-(2,4-dimethoxybenzyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

HRID 11131

反応式

HRID 11131 の反応式
C(N1C2C=[C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:13]3[C:24](=[O:39])[N:25]([CH2:28][C:29]4[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][C:30]=4[O:37][CH3:38])[C:26](=O)[C:12]=3[C:11]=2[C:10]2[CH:9]=[C:8]([O:40][CH3:41])[CH:7]=[CH:6]C1=2)C=C.[CH3:42][N+:43]1([O-])[CH2:48][CH2:47][O:46][CH2:45][CH2:44]1.C[C:51](C)=[O:52].[OH2:54]>Cl.C(OCC)(=O)C.[Os](=O)(=O)(=O)=O>[Cl:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:14]1[C:13]2[C:24](=[O:39])[N:25]([CH2:28][C:29]3[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][C:30]=3[O:37][CH3:38])[C:26](=[O:54])[C:12]=2[C:11]2[C:10]3[CH:9]=[C:8]([O:40][CH3:41])[CH:7]=[CH:6][C:42]=3[N:43]([CH2:48][CH:47]([OH:46])[CH2:51][OH:52])[C:44]=2[CH:45]=1

参加物

7

反応物 3

HCID 82029Methyl morpholine oxideHCID 18366337Propan-2-one--water (1/1)HCID 695854926-Ally-4-(2-chlorophenyl)-2-(2,4-dimethoxybenzyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

生成物 1

HCID 219808174-(2-Chlorophenyl)-6-(2,3-dihydroxypropyl)-2-(2,4-dimethoxybenzyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione収率 94%

試薬・触媒・溶媒 3

HCID 30318Osmium Tetroxide触媒HCID 313Hydrochloric Acid溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of carbazole (288) (80 mg, 0.14 mmol) procedure described in example 298 in acetone/water (4:1, 20 mL) was added N-methylmorpholine N-oxide (33 mg, 0.28 mmol) and osmium tetroxide (176 uL, 4% solution in water, ˜0.028 mmol). The reaction mixture was stirred at room temperature for 18 hours before being diluted with 1N hydrochloric acid and extraction with ethyl acetate. The organic phase was dried, the drying agent was removed and the solution was concentrated to dryness. Chromatography on silica eluting with ethyl acetatelhexane (2:1), followed by crystallization from diethyl ether/hexane gave diol (290) (80 mg, 94%) as a yellow powder, mp 151–156° C. 1H NMR δ [(CD3)2SO] 8.50 (d, J=2.6 Hz, 1H), 7.82 (s, 1H), 7.69 (br d, J=9.0 Hz, 1H), 7.58 (m, 1H), 7.52–7.46 (m, 3H), 7.30 (dd, J=9.0, 2.6 Hz, 1H), 6.95 (d, J=8.4 Hz, 1H), 6.57 (d, J=2.4 Hz, 1H), 6.44 (dd, J=8.4, 2.4 Hz, 1H), 5.02 (d, J=5.0 Hz, 1H), 4.87 (br s, 1H), 4.69 (s, 2H), 4.55 (m, 1H), 4.38 (m, 1H), 3.89 (m, 4H), 3.80 (s, 3H), 3.72 (s, 3H), 3.41 (partially obscured m, 2H). Found: C, 65.32; H, 5.00; N, 4.83. C33H29ClN2O7.1/4H2O requires: C, 65.45; H, 4.91; N, 4.63.

後処理

  1. customThe organic phase was dried
  2. customthe drying agent was removed
  3. concentrationthe solution was concentrated to dryness
  4. customChromatography on silica eluting with ethyl acetatelhexane (2:1), followed by crystallization from diethyl ether/hexane

出典と根拠

ORDレコード
ord-f5196dcb4161474bbb05e2f36ea37b3b
出典データセット
uspto-grants-2006_08
特許番号
US07094798B1

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