Tetrahydrofuran → Cyclopentyl-{5-[(3-ethoxy-2,6-difluoro-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-amine

反応式

[Al+3:29].[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH:1]1([NH:6][c:7]2[n:8][c:9]([S:26][CH3:27])[n:10][cH:11][c:12]2[CH:13]=[N:14][c:15]2[c:16]([F:25])[c:17]([O:22][CH2:23][CH3:24])[cH:18][cH:19][c:20]2[F:21])[CH2:2][CH2:3][CH2:4][CH2:5]1.[H-:28].[H-:31].[H-:32].[H-:33].[Li+:30]>>[CH:1]1([NH:6][c:7]2[n:8][c:9]([S:26][CH3:27])[n:10][cH:11][c:12]2[CH2:13][NH:14][c:15]2[c:16]([F:25])[c:17]([O:22][CH2:23][CH3:24])[cH:18][cH:19][c:20]2[F:21])[CH2:2][CH2:3][CH2:4][CH2:5]1