反応式
C(O[C:4](=O)[CH2:5][C:6]([CH3:8])=[O:7])C.[C:10]([CH2:12][C:13]([NH2:15])=[O:14])#[N:11].P(Cl)(Cl)(Cl)=O>>[C:10]([C:12]1[C:13]([OH:14])=[N:15][CH:8]=[C:6]([OH:7])[C:5]=1[CH3:4])#[N:11]参加物
4
実験手順
Amine was generated by the condensation of ethylacetoacetate with cyanoacetamide followed by reaction with phosphorus oxychloride to provide 3-cyano-2,5-dihydroxy-4-methylpyridine. Hydrogenation with palladium dichloride gave the 3-cyano-4-methylpyridine which was hydrogenated with Raney nickel in ammonia and ethanol to afford the desired amine (J. Org. Chem. 1959, 25, 560.).
出典と根拠
- ORDレコード
- ord-3a88dd9b299e453abb8cca072f727e81
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07094909B2
関連ノート
読み込み中…