Tetrahydrofuran → 6-Fluoro-7-(2-fluoro-4-iodophenylamino)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylic acid

反応式

[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:26][Si:27]([N-:28][Si:29]([CH3:30])([CH3:31])[CH3:32])([CH3:33])[CH3:34].[Cl:1][c:2]1[c:3]([F:15])[c:4](=[O:14])[n:5]2[c:9]([c:10]1[C:11](=[O:12])[OH:13])[CH2:8][CH2:7][CH2:6]2.[F:16][c:17]1[c:18]([NH2:19])[cH:20][cH:21][c:22]([I:24])[cH:23]1.[Li+:25]>>[c:2]1([NH:19][c:18]2[c:17]([F:16])[cH:23][c:22]([I:24])[cH:21][cH:20]2)[c:3]([F:15])[c:4](=[O:14])[n:5]2[c:9]([c:10]1[C:11](=[O:12])[OH:13])[CH2:8][CH2:7][CH2:6]2