Triphenylphosphine → 5-(3-Amino-6-chloro-pyridin-2-yl)-2,2-dimethyl-pent-4-ynoic acid ethyl ester

HRID 112476

反応式

HRID 112476 の反応式
[CH2:29]([CH3:30])[O:31][C:32]([C:33]([CH2:34][C:35]#[CH:36])([CH3:37])[CH3:38])=[O:39].[Cl:20][c:21]1[cH:22][cH:23][c:24]([NH2:28])[c:25]([I:27])[n:26]1.[Cu:43][I:44].[Pd:40]([Cl:41])[Cl:42].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[Cl:20][c:21]1[cH:22][cH:23][c:24]([NH2:28])[c:25]([C:36]#[C:35][CH2:34][C:33]([C:32]([O:31][CH2:29][CH3:30])=[O:39])([CH3:37])[CH3:38])[n:26]1

参加物

6

反応物 5

HCID 11776TriphenylphosphineHCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 14459632Ethyl 2,2-dimethylpent-4-ynoateHCID 184070436-Chloro-2-iodopyridin-3-amine

生成物 1

HCID 597547775-(3-Amino-6-chloro-pyridin-2-yl)-2,2-dimethyl-pent-4-ynoic acid ethyl ester

出典と根拠

ORDレコード
ord-5668cc29a9b74109b3295ad4b1e9db8a
出典データセット
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

関連ノート

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