Dimethylformamide → 1,3-Benzothiazole-6-sulfonyl chloride

HRID 11251

反応式

HRID 11251 の反応式
S(Cl)([Cl:3])=O.[S:5]1[C:9]2[CH:10]=[C:11]([S:14]([OH:17])(=O)=[O:15])[CH:12]=[CH:13][C:8]=2[N:7]=[CH:6]1.CN(C)C=O>ClC(Cl)C>[Cl:3][S:14]([C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[CH:6][S:5][C:9]=2[CH:10]=1)(=[O:17])=[O:15]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 143978241,3-Benzothiazole-6-sulfonic acid

生成物 1

HCID 27951701,3-Benzothiazole-6-sulfonyl chloride

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

Thionyl chloride (4 mL) was added to a suspension of the benzothiazole-6-sulfonic acid (0.60 g, 2.79 mmol) in dichloroethane (15 mL) and the reaction mixture was heated at reflux and dimethylformamide (5 mL) was added to the reaction mixture to yield a clear solution. After 1.5 hr. at reflux, the solvent was removed in vacuo and excess HCl and thionyl chloride was chased by evaporation with dichloroethane.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux
  3. customto yield a clear solution
  4. temperatureat reflux
  5. customthe solvent was removed in vacuo and excess HCl and thionyl chloride
  6. customwas chased by evaporation with dichloroethane

出典と根拠

ORDレコード
ord-65102f31262e4021b5784cb373f3c5c1
出典データセット
uspto-grants-2006_08
特許番号
US07098202B2

関連ノート

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