5-Nitro-2-propoxyphenyl-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one → 2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

HRID 11267

反応式

[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:26][CH2:27][CH2:28][CH3:29])=[C:8]([C:10]2[NH:15][C:14](=[O:16])[C:13]3=[C:17]([CH3:25])[N:18]=[C:19]([CH:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)[N:12]3[N:11]=2)[CH:9]=1)([O-])=O>O1CCCC1.C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:26][CH2:27][CH2:28][CH3:29])=[C:8]([C:10]2[NH:15][C:14](=[O:16])[C:13]3=[C:17]([CH3:25])[N:18]=[C:19]([CH:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)[N:12]3[N:11]=2)[CH:9]=1

参加物

実験手順

Analogously to the procedure of example 42A, 5.13 g (12.96 mmol) of the compound from example 43A are hydrogenated in tetrahydrofuran/ethanol (1:1) using 1.11 g of 10% Pd/C. The product is purified by silica gel chromalography using toluene and ethyl acetate as solvent gradient.

後処理

customThe product is purified by silica gel chromalography

出典と根拠

ORDレコード: ord-4282992d9f884e20a0f83bdc2c8a2c5d
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07098207B2

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

関連ノート