ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → i-Propyl 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4'-amino-3',3'-dimethyl-piperidin-1-yl)-4-oxo-quinoline-3-carboxylate

HRID 11303
ノート
印刷プレビュー

反応式

HRID 11303 の反応式
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:32])=[C:11]([N:16]4[CH2:21][CH2:20][CH:19]([NH:22]C(OC(C)(C)C)=O)[C:18]([CH3:31])([CH3:30])[CH2:17]4)[C:12]=3[O:14][CH3:15])[C:7](=[O:33])[C:6]([C:34]([OH:36])=[O:35])=[CH:5]2)[CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].I[CH2:44][CH2:45][CH3:46]>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:32])=[C:11]([N:16]4[CH2:21][CH2:20][CH:19]([NH2:22])[C:18]([CH3:30])([CH3:31])[CH2:17]4)[C:12]=3[O:14][CH3:15])[C:7](=[O:33])[C:6]([C:34]([O:36][CH:45]([CH3:46])[CH3:44])=[O:35])=[CH:5]2)[CH2:2][CH2:3]1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 103007861-Cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4'-t-butoxycarbonylamino-3',3'-dimethylpiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

生成物 1

HCID 86760219i-Propyl 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4'-amino-3',3'-dimethyl-piperidin-1-yl)-4-oxo-quinoline-3-carboxylate収率 45%

反応条件

温度
70 °C

実験手順

In a dry dimethylformaide (15 ml) was taken a mixture of 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4′-t-butoxycarbonylamino-3′,3′-dimethylpiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid (1 g, 1.98 mmole), K2CO3 (0.275 g, 1.98 mmole) was stirred at 70° C. for 7 hr. Added 1-iodopropane (0.5 g, 2.98 mmole) to reaction mixture and stirred at the same temperature for 16 hr. Solvent was concentrated up to dryness and (15 ml) water was added to it and extracted with chloroform (25 ml×2). Organic layer was separated, dried, concentrated, Which was hydrolysied with trifluoroacetic acid in methylene dichloride and purified on silica column to furnish titled product. Yield 45%, m.p 140–42° C., C24H32FN3O4, m/z 446 (M+1).

後処理

  1. stirringstirred at the same temperature for 16 hr
  2. concentrationSolvent was concentrated up to dryness and (15 ml) water
  3. additionwas added to it
  4. extractionextracted with chloroform (25 ml×2)
  5. customOrganic layer was separated
  6. customdried
  7. concentrationconcentrated
  8. custompurified on silica column

出典と根拠

ORDレコード
ord-a1b74487e4a6436087218ffd783f010b
出典データセット
uspto-grants-2006_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07098219B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート