4'-Fluoroacetophenone → 2,4-Bis(4-fluorophenyl)quinoline

HRID 1149

反応式

HRID 1149 の反応式
[NH2:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=O.[CH3:17][C:18]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)=O.O.C1(C)C(S(O)(=O)=O)=CC=CC=1>O>[F:26][C:23]1[CH:24]=[CH:25][C:20]([C:18]2[CH:17]=[C:4]([C:6]3[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=3)[C:3]3[C:2](=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:1]=2)=[CH:21][CH:22]=1

参加物

5

反応物 3

HCID 98284'-FluoroacetophenoneHCID 98372872-Amino-4'-fluorobenzophenoneHCID 124969952-Methylbenzenesulfonic acid hydrate

生成物 1

HCID 196948162,4-Bis(4-fluorophenyl)quinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
200 °C

実験手順

A flask is loaded with (17) (21.5 g, 0.1 mol), 4-fluoroacetophenone (13.8 g, 0.1 mol), and toluene sulfonic acid monohydrate (3.8 g, 0.02 mol). The flask is heated to 200° C. and the water of condensation removed. After water evolution ceased, the mixture is cooled and the crude solid product is crushed and washed with hot ethanol The product is further recrystallized from toluene.

後処理

  1. customremoved
  2. temperaturethe mixture is cooled
  3. customthe crude solid product is crushed
  4. washwashed with hot ethanol The product
  5. customis further recrystallized from toluene

出典と根拠

ORDレコード
ord-505bc94ed0b24d42b247b9173702273a
出典データセット
uspto-grants-1998_03
特許番号
US05723573

関連ノート

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