Hydrogen Bromide → 5,8-Quinoxalinediol
反応式
C[O:2][C:3]1[CH:12]=[CH:11][C:10]([O:13]C)=[C:9]2[C:4]=1[N:5]=[CH:6][CH:7]=[N:8]2.Br>C(O)(=O)C>[OH:13][C:10]1[CH:11]=[CH:12][C:3]([OH:2])=[C:4]2[C:9]=1[N:8]=[CH:7][CH:6]=[N:5]2参加物
4
実験手順
Ten grams of 5,8-dimethoxyquinoxaline were dissolved in 100 ml. of glacial acetic acid. After 60 ml. of 48% hydrobromic acid were added to the solution, the reaction was allowed to reflux overnight. The solution was evaporated to dryness in vacuo and a solution of 5% sodium bicarbonate was added until the reaction was basic. The solution was extracted several times with methylene chloride. The combined methylene chloride extracts were dried with sodium sulfate and evaporated to give an amorphous powder which was used without purification for the subsequent reactions.
後処理
- temperatureto reflux overnight
- customThe solution was evaporated to dryness in vacuo
- additiona solution of 5% sodium bicarbonate was added until the reaction
- extractionThe solution was extracted several times with methylene chloride
- dry with materialThe combined methylene chloride extracts were dried with sodium sulfate
- customevaporated
- customto give an amorphous powder which
- customwas used without purification for the subsequent reactions
出典と根拠
- ORDレコード
- ord-c2b4993bd13e46808f7ddc4e35a70d2e
- 出典データセット
- uspto-grants-1984_12
- 特許番号
- US04486432
反応ノート
読み込み中…