反応式
CS([CH2-])=O.[Na+].[H-].[Na+].[NH2:8][C:9]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:10]=1[NH:11][C:12]1[C:16]([C:17](OCC)=[O:18])=[CH:15][N:14]([CH3:22])[N:13]=1>CS(C)=O>[F:27][C:25]1[CH:24]=[CH:23][C:10]2[NH:11][C:12]3=[N:13][N:14]([CH3:22])[CH:15]=[C:16]3[C:17](=[O:18])[NH:8][C:9]=2[CH:26]=1参加物
5
反応条件
- 温度
- 65 °C
実験手順
A solution of sodium methyl sulphinyl methanide was generated by stirring sodium hydride (50% oil dispersion, 1.5 g) in dry dimethylsulphoxide (15 ml) at 65° C. until gas evolution ceased. A solution of ethyl 3-(2-amino-4-fluoroanilino)-1-methylpyrazole-4-carboxylate (2.7 g) dissolved in dry dimethyl sulphoxide (5 ml) was added dropwise and the mixture stirred at 65° C. for 20 minutes. The mixture was poured on to excess ice-water, filtered and dried to give the title compound which was crystallised from chloroform-hexane m.p. 264° C.
後処理
- additionwas added dropwise
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-299f347667914d7cb98c16500adfcc49
- 出典データセット
- uspto-grants-1984_12
- 特許番号
- US04486591
関連ノート
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