Water → HCID 70467484、化合物

HRID 1153879ノート

反応式

HRID 1153879 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=O.C([CH:16](C([NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25]C=1)=O)[C:17]([OH:19])=[O:18])(O)=O.[NH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1.[OH2:35].[C:36]1([CH3:42])C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=[CH:42][C:36]([NH:29][C:34]1[C:16](=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:17]([O-:19])=[O:18])=[O:35].[NH2+:22]1[CH2:23][CH2:28][CH2:27][CH2:26][CH2:25]1

参加物

6

反応物 5

HCID 962WaterHCID 1140TolueneHCID 8082PiperidineHCID 8419VeratraldehydeHCID 20222317HCID 20222317、化合物

生成物 1

HCID 70467484HCID 70467484、化合物収率 94.8%

実験手順

A solution of 8.4 g of 3,4-dimethoxybenzaldehyde, 11.4 g of 2-carboxymalonanilic acid, and 4.3 g of piperidine in 50 ml of toluene is heated for 3 hours under reflux with continuous removal of water during the reaction period. After the completion of the reaction, the reaction mixture is cooled and the precipitated crystals are collected by filtration and dried to obtain 19.5 g of piperidinium N-(3,4-dimethoxycinnamoyl)anthranilate (94.8% yield), as confirmed by elemental analysis and spectroscopy.

後処理

  1. customAfter the completion of the reaction
  2. temperaturethe reaction mixture is cooled
  3. filtrationthe precipitated crystals are collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-a4dc85006a8d42a2bdcb1281a0c1024c
出典データセット
uspto-grants-1984_12
特許番号
US04486597

反応ノート

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