Hydrochloric Acid → N-(3',4'-dimethoxycinnamoyl)anthranilic acid

HRID 1153882ノート

反応式

HRID 1153882 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH:6]=[CH:7][C:8]([NH:10][C:11]1[C:12](=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:13]([O-:15])=[O:14])=[O:9].[NH2+]1CCOCC1.Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH:6]=[CH:7][C:8]([NH:10][C:11]1[C:12](=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:13]([OH:15])=[O:14])=[O:9]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70467859HCID 70467859、化合物

生成物 1

HCID 5527N-(3',4'-dimethoxycinnamoyl)anthranilic acid収率 98%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 20 g quantity of morpholinium N-(3,4-dimethoxycinnamoyl)anthranilate is dissolved in 40 ml of water and the resultant solution is added dropwise to 45 ml of diluted hydrochloric acid (5 ml of conc. hydrochloric acid and 40 ml of water) with stirring. The precipitated crystals which form are collected by filtration, washed with water and then dried at 90°-100° C. under reduced pressure for 3 hours to yield 15.5 g of N-(3,4-dimethoxycinnamoyl)anthranilic acid (98% yield). The compound is confirmed as identical to that obtained in EXAMPLE VI.

後処理

  1. filtrationThe precipitated crystals which form are collected by filtration
  2. washwashed with water
  3. customdried at 90°-100° C. under reduced pressure for 3 hours

出典と根拠

ORDレコード
ord-859d77f5e83a481592deb5243f6c1756
出典データセット
uspto-grants-1984_12
特許番号
US04486597

反応ノート

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