Phenyl Isothiocyanate → HCID 4244266、化合物

HRID 1153968ノート

反応式

HRID 1153968 の反応式
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:10][C:11]1[CH:23]=[CH:22][C:14]([CH2:15][NH:16][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:15][N:16]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[S:9])=[CH:22][CH:23]=1

参加物

4

反応物 2

HCID 7673Phenyl IsothiocyanateHCID 834084HCID 834084、化合物

生成物 1

HCID 4244266HCID 4244266、化合物収率 84%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

6.75 g (0.05 mol) of phenyl isothiocyanate were rapidly added dropwise to a solution of 9.65 g (0.05 mol) of N-4-fluorobenzyl-N-cyclopentylamine in 80 ml of toluene. The mixture was heated to the boil for 30 minutes, the solvent was distilled off in vacuo, and the residue was recrystallized from isopropanol. 13.8 g of N-4-fluorobenzyl-N-cyclopentyl-N'-phenylthiourea of melting point 135° C. were obtained.

後処理

  1. temperatureThe mixture was heated to the boil for 30 minutes
  2. distillationthe solvent was distilled off in vacuo
  3. customthe residue was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-0996041c7caf44249cfbd958caacc99b
出典データセット
uspto-grants-1984_12
特許番号
US04487783

反応ノート

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