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Water → 2,3,5-Trimethylanisole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | 2,3,5-Trimethylphenol | HCID 12769 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2,3,5-Trimethylanisole | HCID 88555 | — |
反応手順
In 100 ml of DMSO were dissolved 10 g of 2,3,5-trimethylphenol and 10.4 ml of methyl iodide. Under ice-cooling, 5.6 g of 60% sodium hydride in oil was added, and the mixture was stirred at room temperature for 10 hours. After addition of water, the extraction with ether was carried out. The ether layer was washed with water and dried over anhydrous sodium sulfate. Removal of the solvent by distillation leaves the oily substance. Yield 12.9 g (quantitative)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04487726 |
| 出典データセット | uspto-grants-1984_12 |
| ORD ID | ord-2189fa23ece643879df3626b0fc3c881 |
| 出典メモ | uspto-grants-1984_12 |