反应详情

In 100 ml of DMSO were dissolved 10 g of 2,3,5-trimethylphenol and 10.4 ml of methyl iodide. Under ice-cooling, 5.6 g of 60% sodium hydride in oil was added, and the mixture was stirred at room temperature for 10 hours. After addition of water, the extraction with ether was carried out. The ether layer was washed with water and dried over anhydrous sodium sulfate. Removal of the solvent by distillation leaves the oily substance. Yield 12.9 g (quantitative)

1. temperatureUnder ice-cooling
2. extractionthe extraction with ether
3. washThe ether layer was washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. customRemoval of the solvent
6. distillationby distillation
7. customleaves the oily substance