Dichloromethane → N-(3-imidazol-1-ylpropyl)furan-2-carboxamide

反応式

Cl.Cl.[N:3]1([CH2:8][CH2:9][CH2:10][NH2:11])[CH:7]=[CH:6][N:5]=[CH:4]1.[OH-:12].[Na+].[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1Cl.Cl[CH2:21]Cl>>[N:3]1([CH2:8][CH2:9][CH2:10][NH:11][C:21]([C:15]2[O:14][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH:7]=[CH:6][N:5]=[CH:4]1

参加物

反応物 4

HCID 6344Dichloromethane2 回

HCID 14798Sodium Hydroxide

HCID 1378562-Chlorofuran

HCID 122509693-(Imidazole-1-yl)-propylamine Dihydrochloride

生成物 1

HCID 3246788N-(3-imidazol-1-ylpropyl)furan-2-carboxamide

実験手順

A mixture of 1.98 g. of 1H-imidazole-1-propanamine dihydrochloride and 30 ml. of 1N sodium hydroxide was stirred at room temperature. A mixture of 0.98 ml. of 2-furanyl chloride and 50 ml. of dichloromethane was added and stirring was continued overnight. More dichloromethane was added, the organic layer was separated, washed twice with water and concentrated, giving 1.0 g. of the desired product, m.p. 111°-113° C.