Eclazolast → 5-Chloro-N-(2-ethoxyethyl)-1,3-benzoxazole-2-carboxamide
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([O:12]CCOCC)=O)=[N:7][C:6]=2[CH:18]=1.[CH2:19]([O:21][CH2:22][CH2:23][NH2:24])[CH3:20]>C1COCC1>[CH2:19]([O:21][CH2:22][CH2:23][NH:24][C:10]([C:8]1[O:9][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:18][C:6]=2[N:7]=1)=[O:12])[CH3:20]参加物
4
実験手順
A mixture of 2-ethoxyethyl 5-chlorobenzoxazol-2-carboxylate (10 g) and 3.5 g of ethoxyethylamine in 10 ml of THF was stirred at room temperature for 2 hours. The precipitated product was filtered and washed well with hexane to give 9 g of product; mp 110°-111° C.
後処理
- filtrationThe precipitated product was filtered
- washwashed well with hexane
出典と根拠
- ORDレコード
- ord-e4ad9de29a11461c9ba5b669f4a581a9
- 出典データセット
- uspto-grants-1984_12
- 特許番号
- US04490373
反応ノート
読み込み中…