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Dimethylformamide → 1-(4-Methoxyphenyl)-4-(4-nitrophenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1-Chloro-4-nitrobenzene | HCID 7474 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(4-Methoxyphenyl)-4-(4-nitrophenyl)piperazine | HCID 5134657 | 67% |
反応手順
A mixture of 13.4 parts of 1-(4-methoxyphenyl)piperazine dihydrochloride, 7.9 parts of 1-chloro-4-nitrobenzene, 10 parts of potassium carbonate and 90 parts of N,N-dimethylformamide is stirred and refluxed overnight. The reaction mixture is diluted with water and the product is extracted twice with trichloromethane. The combined extracts are dried, filtered and evaporated. The residue is triturated in 4-methyl-2-pentanone. The product is filtered off and crystallized from 1,4-dioxane, yielding 10.5 parts (67%) of 1-(4-methoxyphenyl)-4-(4-nitrophenyl)piperazine; mp. 195.1° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04490530 |
| 出典データセット | uspto-grants-1984_12 |
| ORD ID | ord-5a7c8710c45e4270a123e201951785e5 |
| 出典メモ | uspto-grants-1984_12 |