反应详情

A mixture of 13.4 parts of 1-(4-methoxyphenyl)piperazine dihydrochloride, 7.9 parts of 1-chloro-4-nitrobenzene, 10 parts of potassium carbonate and 90 parts of N,N-dimethylformamide is stirred and refluxed overnight. The reaction mixture is diluted with water and the product is extracted twice with trichloromethane. The combined extracts are dried, filtered and evaporated. The residue is triturated in 4-methyl-2-pentanone. The product is filtered off and crystallized from 1,4-dioxane, yielding 10.5 parts (67%) of 1-(4-methoxyphenyl)-4-(4-nitrophenyl)piperazine; mp. 195.1° C.

1. temperaturerefluxed overnight
2. extractionthe product is extracted twice with trichloromethane
3. customThe combined extracts are dried
4. filtrationfiltered
5. customevaporated
6. customThe residue is triturated in 4-methyl-2-pentanone
7. filtrationThe product is filtered off
8. customcrystallized from 1,4-dioxane