Hydrogen Bromide → 4-[4-(4-Aminophenyl)piperazin-1-yl]phenol

HRID 1154748

反応式

HRID 1154748 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Br>O>[NH2:21][C:18]1[CH:17]=[CH:16][C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:6]3[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=3)[CH2:10][CH2:11]2)=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 154406Benzenamine, 4-(4-(4-methoxyphenyl)-1-piperazinyl)-

生成物 1

HCID 102210654-[4-(4-Aminophenyl)piperazin-1-yl]phenol収率 44%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 30 parts of 4-[4-(4-methoxyphenyl)-1-piperazinyl]benzenamine and 300 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 10 days. The reaction mixture is evaporated and the residue is alkalized with sodium hydroxide. The mixture is filtered and the filtrate is acidified with acetic acid. The precipitated product is filtered off and crystallized from 1,4-dioxane, yielding 12 parts (44%) of 4-[4-(4-aminophenyl)-1-piperazinyl]phenol.

後処理

  1. temperaturerefluxed for 10 days
  2. customThe reaction mixture is evaporated
  3. filtrationThe mixture is filtered
  4. filtrationThe precipitated product is filtered off
  5. customcrystallized from 1,4-dioxane

出典と根拠

ORDレコード
ord-476e78f0e2374da3afda6f1c0fbd12bb
出典データセット
uspto-grants-1984_12
特許番号
US04490530

関連ノート

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