Hydrochloric Acid → 7-Amino-3-methylenecepham-4-carboxylic acid
反応式
CC(O[CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])=O.Cl.[OH-].[Na+]>O.[Zn]>[NH2:13][CH:10]1[C:11](=[O:12])[N:8]2[CH:7]([C:16]([OH:18])=[O:17])[C:6](=[CH2:5])[CH2:15][S:14][C@H:9]12参加物
6
実験手順
Zinc powder (40 g) was added to a solution of 7-aminocephalosporanic acid (27.3 g) and conc. hydrochloric acid (70 ml.) in water (200 ml.) for 5° C. and stirred for an hour. The resultant solution was adjusted to pH 4.0 with 4 N sodium hydroxide and concentrated to 100 ml. of the volume. After adjusting the solution to pH 4.0, the solution was allowed to stand under cooling overnight. The precipitates were collected by filtration to give 7-amino-3-methylenecepham-4-carboxylic acid (11.96 g.).
後処理
- concentrationconcentrated to 100 ml
- temperatureunder cooling overnight
- filtrationThe precipitates were collected by filtration
出典と根拠
- ORDレコード
- ord-d24ac584d86e472ebaf35bbb4ce2f5ee
- 出典データセット
- uspto-grants-1981_11
- 特許番号
- US04298529
反応ノート
読み込み中…