Methyl iodide → HCID 12813181、化合物

反応式

[F:1][C:2]([F:26])([F:25])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]2[C:13](=[O:14])[C:12]([C:15]3[CH:16]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:19][CH:20]=3)=[CH:11][NH:10]2)[CH:4]=1.[CH3:27]I>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]2[C:13](=[O:14])[C:12]([C:15]3[CH:16]=[C:17]([C:21]([F:22])([F:23])[F:24])[CH:18]=[CH:19][CH:20]=3)=[CH:11][N:10]2[CH3:27])[CH:4]=1

参加物

反応物 2

HCID 6328Methyl iodide

HCID 12813180HCID 12813180、化合物

生成物 1

HCID 12813181HCID 12813181、化合物

実験手順

A 3.5 gram portion of the atropic ester of Example 1 was reacted with 2.7 grams α,α,α-trifluoro-3-tolylhydrazine hydrochloride in the presence of triethylamine to produce 2.4 grams 1,4-bis-(α,α,α-trifluoro-3-tolyl)-3-pyrazolin-5-one, m.p. 207°-208° C. A 1.8 gram portion of the above pyrazolinone was alkylated with 2 grams methyl iodide to produce 1.25 grams of the desired product, m.p. 110°-111° C.

出典と根拠

ORDレコード: ord-b2b58c4860314d70abbea6ce8ca149bb
出典データセット: uspto-grants-1981_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04299614

反応ノート

読み込み中…

参加物