Sodium Hydroxide → Zomepirac
反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:8]2[N:12]([CH3:13])[C:11]([CH2:14][C:15]([O-:17])=[O:16])=[CH:10][C:9]=2[CH3:18])=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+]>>[CH3:18][C:9]1[CH:10]=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[N:12]([CH3:13])[C:8]=1[C:6]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:20][CH:19]=1)=[O:7]参加物
3
実験手順
About 31 grams of the lower alkyl ester form of 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetate are saponified in 225 ml. of an aqueous reaction medium containing 0.12 M.NaOH. Saponification is carried out at about 90° C. for a period of from about 2 to 4 hours. At the end of this period, the aqueous saponification medium is cooled to a temperature of 0° to 5° C. The resulting insoluble first crop of acetate salt product is removed from the aqueous mother liquor. An 86-88% yield of Zomepirac [sodium 5-(p-chlorobenzoyl)-1,4 -dimethylpyrrole-2-acetate] is thereby realized based on the amount of ester initially employed.
後処理
- additionof an aqueous reaction medium containing 0.12 M
- temperatureAt the end of this period, the aqueous saponification medium is cooled to a temperature of 0° to 5° C